W. W. “Mo” Cleland: A Catalytic Life

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• 作者：Debra Dunaway-Mariano ; Hazel M. Holden ; Frank M. Raushel
• 刊名：Biochemistry
• 出版年：2013
• 出版时间：December 23, 2013
• 年：2013
• 卷：52
• 期：51
• 页码：9092-9096
• 全文大小：246K
• ISSN：1520-4995

文摘

Professor W. Wallace Cleland, the architect of modern steady-state enzyme kinetics, died on March 6, 2013, from injuries sustained in a fall outside of his home. He will be most remembered for giving the enzyme community Ping-Pong kinetics and the invention of dithiothreitol (DTT). He pioneered the utilization of heavy atom isotope effects for the elucidation of the chemical mechanisms of enzyme-catalyzed reactions. His favorite research journal was Biochemistry, in which he published more than 135 papers beginning in 1964 with the disclosure of DTT.