Application of the Chiral Bis(phosphine) Monoxide Ligand to Catalytic Enantioselective Addition of Dialkylzinc Reagents to bs.acs.org/images/gifchars/beta2.gif" border="0" align="mi

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• 作者：Alexandre Cô ; t&eacute ; Vincent N. G. Lindsay ; Andr&eacute ; B. Charette
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：January 4, 2007
• 年：2007
• 卷：9
• 期：1
• 页码：85 - 87
• 全文大小：70K
• 年卷期：v.9,no.1(January 4, 2007)
• ISSN：1523-7052

文摘

BLE>bscribe/journals/orlef7/9/i01/figures/ol062792tn00002.gif" ALIGN="left" HSPACE=5>Me-DuPHOS monoxide is shown to be a very effective ligand in the enantioselective copper-catalyzed addition of dialkylzinc reagents tobeta2.gif" BORDER=0 ALIGN="middle">-nitroalkenes providing access to chiral nitroalkanes. The major advantages of this process are high yields, broad and complementarysubstrate scope, and high enantioselectivities. The effect of achiral dummy ligands as an additive has also been documented.