Probing Proton-Proton Proximities in the Solid State: High-Resolution Two-Dimensional 1H-1H Double-Quantum CRAMPS NMR Spectroscopy
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- 作者：Steven P. Brown ; Anne Lesage ; Bé ; né ; dicte Elena ; and Lyndon Emsley
- 刊名：Journal of the American Chemical Society
- 出版年：2004
- 出版时间：October 20, 2004
- 年：2004
- 卷：126
- 期：41
- 页码：13230 - 13231
- 全文大小：63K
- 年卷期：v.126,no.41(October 20, 2004)
- ISSN：1520-5126
文摘
A new 1H DQ (double-quantum) CRAMPS (combined rotation and multiple-pulse sequence) solid-state nuclear magnetic resonance experiment incorporating DUMBO homonuclear 1H dipolar decoupling is presented. The major resolution enhancement enables DQ peaks corresponding to all 22 close (<3.5 Å) proton-proton proximities in the dipeptide 
-AspAla to be observed. In particular, the DQ CRAMPS spectrum provides access to the alkyl region of the spectrum and yields a clear assignment of the two CH and two diastereotopic CH2 proton resonances.
-AspAla to be observed. In particular, the DQ CRAMPS spectrum provides access to the alkyl region of the spectrum and yields a clear assignment of the two CH and two diastereotopic CH2 proton resonances.