Phycomysterols and Other Sterols from the Fungus Phycomyces blakesleeanus
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- 作者：Alejandro F. Barrero ; J. Enrique Oltra ; Juan A. Poyatos ; David Jimé ; nez ; and Eulalia Oliver
- 刊名：Journal of Natural Products
- 出版年：1998
- 出版时间：December 1998
- 年：1998
- 卷：61
- 期：12
- 页码：1491 - 1496
- 全文大小：131K
- 年卷期：v.61,no.12(December 1998)
- ISSN：1520-6025
文摘
In the search for novel bioactive products from filamentous fungi, sterols and triterpenoids found inPhycomyces blakesleeanus were analyzed using semipreparative HPLC, GC-MS, and NMR techniques.Structures proposed for the three new compounds identified, phycomysterol A (1), phycomysterol B (2),and neoergosterol (3), were confirmed by chemical synthesis. Phycomysterols possess a new natural19-norergostane skeleton with an aromatic B ring. Phycomysterol A showed anti-HIV activity.