Alvaradoins E-N, Antitumor and Cytotoxic Anthracenone C-Glycosides from the Leaves of Alvaradoa haitiensis
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- 作者：Sharnelle S. Phifer ; Dongho Lee ; Eun-Kyoung Seo ; Nam-Cheol Kim ; Tyler N. Graf ; David J. Kroll ; Herná ; n A. Navarro ; Robert A. Izydore ; Francisco Jimé ; nez ; Ricardo Garcia ; William C. Rose ; C
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：June 2007
- 年：2007
- 卷：70
- 期：6
- 页码：954 - 961
- 全文大小：126K
- 年卷期：v.70,no.6(June 2007)
- ISSN：1520-6025
文摘
Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoidcarcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E-N(1-10), along with the known compound chrysophanol (11). The cytotoxicity of all compounds was evaluated, andpreliminary structure-activity relationships are suggested. The most potent compounds in the in vitro assays (1 and 2)were evaluated in vivo versus the P388 (murine lymphocytic leukemia) model, and alvaradoin E (1) showed antileukemicactivity (125% T/C) at a dose of 0.2 mg kg-1 per injection when administered intraperitoneally.