Enantioselective Pd-Catalyzed Allylation Reaction of Fluorinated Silyl Enol Ethers
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- 作者：É ; tienne Bé ; langer ; Katy Cantin ; Olivier Messe ; Mé ; lanie Tremblay ; Jean-Franç ; ois Paquin
- 刊名：Journal of the American Chemical Society
- 出版年：2007
- 出版时间：February 7, 2007
- 年：2007
- 卷：129
- 期：5
- 页码：1034 - 1035
- 全文大小：51K
- 年卷期：v.129,no.5(February 7, 2007)
- ISSN：1520-5126
文摘
An enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers is reported. This reaction provides a stereoselective and efficient approach to allylated tertiary 
-fluoroketones from achiral fluorinated precursors. A variety of cyclic silyl enol ether can be used, and the yields of the desired products range from 52 to 93%, and the enantiomeric excesses range from 83 to 95% ee.
-fluoroketones from achiral fluorinated precursors. A variety of cyclic silyl enol ether can be used, and the yields of the desired products range from 52 to 93%, and the enantiomeric excesses range from 83 to 95% ee.