Straightforward Methodology for the Enantioselective Synthesis of Benzo[a]- and Indolo[2,3-a]quinolizidines
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- 作者：Mercedes Amat ; Maria M. M. Santos ; Oriol Bassas ; Nú ; ria Llor ; Carmen Escolano ; Arantxa Gó ; mez-Esqué ; Elies Molins ; Steven M. Allin ; Vickie McKee ; Joan Bosch
- 刊名：Journal of Organic Chemistry
- 出版年：2007
- 出版时间：July 6, 2007
- 年：2007
- 卷：72
- 期：14
- 页码：5193 - 5201
- 全文大小：201K
- 年卷期：v.72,no.14(July 6, 2007)
- ISSN：1520-6904
文摘
-oxo(di)esterwith either (S)-(3,4-dimethoxyphenyl)alaninol or (S)-tryptophanol in a process involving a dynamic kineticresolution and/or the differentiation of enantiotopic or diastereotopic ester groups, and (ii) a subsequentstereocontrolled cyclization on the aromatic ring taking advantage of the masked N-acyl iminium ionpresent in the resulting oxazolopiperidone lactams.