Free Radical Scavengers and Antioxidants from Lemongrass (Cymbopogon citratus (DC.) Stapf.)
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- 作者：José ; Cheel ; Cristina Theoduloz ; Jaime Rodrí ; guez ; and Guillermo Schmeda-Hirschmann
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2005
- 出版时间：April 6, 2005
- 年：2005
- 卷：53
- 期：7
- 页码：2511 - 2517
- 全文大小：99K
- 年卷期：v.53,no.7(April 6, 2005)
- ISSN：1520-5118
文摘
Methanol, MeOH/water extracts, infusion, and decoction of Cymbopogon citratus were assessed forfree radical scavenging effects measured by the bleaching of the 1,1-diphenyl-2-picryl-hydrazyl (DPPH)radical, scavenging of the superoxide anion, and inhibition of the enzyme xanthine oxidase (XO) andlipid peroxidation in human erythrocytes. The extracts presented effect in the DPPH and superoxideanion assay, with values ranging between 40 and 68% and 15-32% at 33 and 50 
g/mL, respectively,inhibited lipid peroxidation in erythrocytes by 19-71% at 500 g/mL and were inactive toward theXO at 50 g/mL. Isoorientin, isoscoparin, swertiajaponin, isoorientin 2' '-O-rhamnoside, orientin,chlorogenic acid, and caffeic acid were isolated and identified by spectroscopic methods. Isoorientinand orientin presented similar activities toward the DPPH (IC50: 9-10 M) and inhibited lipidperoxidation by 70% at 100 g/mL. Caffeic and chlorogenic acid were active superoxide anionscavengers with IC50 values of 68.8 and 54.2 M, respectively, and a strong effect toward DPPH.Caffeic acid inhibited lipid peroxidation by 85% at 100 g/mL.Keywords: Cymbopogon citratus; free radical scavengers; antioxidants; flavonoid C-glycosides
g/mL, respectively,inhibited lipid peroxidation in erythrocytes by 19-71% at 500 g/mL and were inactive toward theXO at 50 g/mL. Isoorientin, isoscoparin, swertiajaponin, isoorientin 2' '-O-rhamnoside, orientin,chlorogenic acid, and caffeic acid were isolated and identified by spectroscopic methods. Isoorientinand orientin presented similar activities toward the DPPH (IC50: 9-10 M) and inhibited lipidperoxidation by 70% at 100 g/mL. Caffeic and chlorogenic acid were active superoxide anionscavengers with IC50 values of 68.8 and 54.2 M, respectively, and a strong effect toward DPPH.Caffeic acid inhibited lipid peroxidation by 85% at 100 g/mL.Keywords: Cymbopogon citratus; free radical scavengers; antioxidants; flavonoid C-glycosides