Online Spectroscopy and Multivariate Data Analysis as a Combined Tool for Process Monitoring and Reaction Optimization
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- 作者：Hans-René ; Bj
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- 刊名：Organic Process Research & Development
- 出版年：2004
- 出版时间：May 2004
- 年：2004
- 卷：8
- 期：3
- 页码：495 - 503
- 全文大小：376K
- 年卷期：v.8,no.3(May 2004)
- ISSN：1520-586X
文摘
Multivariate modeling and spectroscopy taken together constitute a powerful tool applicable to both process monitoringand to process and reaction optimizing. The present articleestablishes how near-IR spectroscopy utilizing a fiber-opticaltransmission probe can be combined with principal componentanalysis to extract concentration profiles from a set of spectrarecorded during the course of a reaction. Moreover, it isdemonstrated how to easily determine the end-point (optimizedreaction time, that is, the minimized time) of a reaction, and asimple calibration for quantitative analysis is demonstrated.