Serine versus Threonine Glycosylation: The Methyl Group Causes a Drastic Alteration on the Carbohydrate Orientation and on the Surrounding Water Shell
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- 作者：Francisco Corzana ; Jesú ; s H. Busto ; Gonzalo Jimé ; nez-Osé ; s ; Marisa Garcí ; a de Luis ; Juan L. Asensio ; Jesú ; s Jimé ; nez-Barbero ; Jesú ; s M. Peregrina ; Alberto Aven
- 刊名：Journal of the American Chemical Society
- 出版年：2007
- 出版时间：August 1, 2007
- 年：2007
- 卷：129
- 期：30
- 页码：9458 - 9467
- 全文大小：642K
- 年卷期：v.129,no.30(August 1, 2007)
- ISSN：1520-5126
文摘
Different behavior has been observed for the 
torsion angle of the glycosidic linkagesof D-GalNAc-Ser and D-GalNAc-Thr motifs, allowing the carbohydrate moiety to adopt a completely differentorientation. In addition, the fact that the water pockets found in 
-D-GalNAc-Thr differ from those obtainedfor its serine analogue could be related to the different capability that the two model glycopeptides haveto structure the surrounding water. This fact could have important biological inferences (i.e., antifreezeactivity).
torsion angle of the glycosidic linkagesof D-GalNAc-Ser and D-GalNAc-Thr motifs, allowing the carbohydrate moiety to adopt a completely differentorientation. In addition, the fact that the water pockets found in -D-GalNAc-Thr differ from those obtainedfor its serine analogue could be related to the different capability that the two model glycopeptides haveto structure the surrounding water. This fact could have important biological inferences (i.e., antifreezeactivity).