Hydroxyalkenylresorcinols from Stylogyne turbacensis
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- 作者：Carlos Jimé ; nez-Romero ; Daniel Torres-Mendoza ; Luis David Ureñ ; a Gonzá ; lez ; Eduardo Ortega-Barrí ; a ; Kerry L. McPhail ; William H. Gerwick ; Luis Cubilla-Rios
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：August 2007
- 年：2007
- 卷：70
- 期：8
- 页码：1249 - 1252
- 全文大小：57K
- 年卷期：v.70,no.8(August 2007)
- ISSN：1520-6025
文摘
Two new compounds, 5-(11'(S)-hydroxy-8'-heptadecenyl)resorcinol (3) and 5-(12'(S)-hydroxy-8',14'-heptadecadienyl)resorcinol (4), were isolated from the leaves of Stylogyne turbacensis together with the known analogue metabolites 1and 2. Compounds 3 and 4 showed the strongest activity in the leishmania assay, 7 and 3 
M, respectively, whilecompounds 1, 2, and 4 showed moderate activity against a drug-resistant strain of Trypanosoma cruzi with IC50 valuesof 30, 25, and 22 M, respectively. Additional testing in MCF-7 and NCI-H460 was performed for compounds 3 and4. The structures of compounds 1-4 were elucidated using NMR, MS, and other spectroscopic data. The absolutestereochemistry of compounds 3 and 4 was also investigated using the Mosher ester approach. Peracetylated derivativesof these four metabolites were produced and their activities determined in the Trypanosoma cruzi assay.
M, respectively, whilecompounds 1, 2, and 4 showed moderate activity against a drug-resistant strain of Trypanosoma cruzi with IC50 valuesof 30, 25, and 22 M, respectively. Additional testing in MCF-7 and NCI-H460 was performed for compounds 3 and4. The structures of compounds 1-4 were elucidated using NMR, MS, and other spectroscopic data. The absolutestereochemistry of compounds 3 and 4 was also investigated using the Mosher ester approach. Peracetylated derivativesof these four metabolites were produced and their activities determined in the Trypanosoma cruzi assay.