Palladium-Catalyzed Direct C-H Arylation of N-Iminopyridinium Ylides: Application to the Synthesis of (±)-Anabasine

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• 作者：Alexandre Lariv&eacute ; e ; James J. Mousseau ; Andr&eacute ; B. Charette
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：January 9, 2008
• 年：2008
• 卷：130
• 期：1
• 页码：52 - 54
• 全文大小：77K
• 年卷期：v.130,no.1(January 9, 2008)
• ISSN：1520-5126

文摘

Palladium-catalyzed direct C-H arylation of N-iminopyridinium ylides provides a powerful and versatile method for the synthesis of functionalized piperidines in good yields. Chemoselective functionalization of the pyridinium ring in the presence of a pyridine substituent is possible as exemplified by the expedient synthesis of anabasine in 61% overall yield over three steps.