Direct C-Glycosylation by Indium-Mediated Alkynylation on Sugar Anomeric Position

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• 作者：Nadè ; ge Lubin-Germain ; Jean-Pierre Baltaze ; Alexis Coste ; Agnè ; s Hallonet ; Hugo Laur&eacute ; ano ; Gr&eacute ; gory Legrave ; Jacques Uziel ; Jacques Aug&eacute
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：March 6, 2008
• 年：2008
• 卷：10
• 期：5
• 页码：725 - 728
• 全文大小：80K
• 年卷期：v.10,no.5(March 6, 2008)
• ISSN：1523-7052

文摘

<TR>Indium-mediated alkynylation reaction was studied for the direct preparation of C-glycosides. Easily available starting sugar derivatives withan acetyl group at the anomeric position were tested as electrophiles toward alkynylindium reagents under Barbier conditions. Good yieldsand stereoselectivities were observed during the reaction. The alkynylation was applied to the synthesis of an -(16)-C-disaccharide analogueof isomaltoside.