Cascade Synthesis of Polyoxygenated 6H,11H-[2]Benzopyrano-[4,3-c][1]benzopyran-11-ones

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作者：Mikael I. Naumov ; Sergey A. Sutirin ; Andrey S. Shavyrin ; Olga G. Ganina ; Irina P. Beletskaya ; V&eacute ; ronique Bourgarel-Rey ; S&eacute ; bastien Combes ; Jean-Pierre Finet ; Alexey Yu. Fedorov
刊名：Journal of Organic Chemistry
出版年：2007
出版时间：April 27, 2007
年：2007
卷：72
期：9
页码：3293 - 3301
全文大小：166K
年卷期：v.72,no.9(April 27, 2007)
ISSN：1520-6904

文摘

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2-(Methoxymethoxymethyl)aryllead triacetates, obtained in situ from the corresponding arylboronic acids,reacted with 4-hydroxycoumarins, leading to 3-(2-methoxymethoxymethyl)aryl-4-hydroxycoumarinderivatives in good to high yields. These compounds underwent a cascade sequence of reactions,deprotection-halogenation-annulation, to afford polyoxygenated tetracyclic 6H,11H-[2]benzopyrano-[4,3-c] [1]benzopyran-11-ones in good yields. Some compounds showed a moderate cytotoxicity againsthuman epithelial mammary HBL100 cells.

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