Interactions of Monoamine Oxidases with the Antiepileptic Drug Zonisamide: Specificity of Inhibition and Structure of the Human Monoamine Oxidase B Complex

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• 作者：Claudia Binda ; Milagros Aldeco ; Andrea Mattevi ; Dale E. Edmondson
• 刊名：Journal of Medicinal Chemistry
• 出版年：2011
• 出版时间：February 10, 2011
• 年：2011
• 卷：54
• 期：3
• 页码：909-912
• 全文大小：750K
• 年卷期：v.54,no.3(February 10, 2011)
• ISSN：1520-4804

文摘

The binding of zonisamide to purified, recombinant monoamine oxidases (MAOs) has been investigated. It is a competitive inhibitor of human MAO B (K_i = 3.1 卤 0.3 渭M), of rat MAO B (K_i = 2.9 卤 0.5 渭M), and of zebrafish MAO (K_i = 30.8 卤 5.3 渭M). No inhibition is observed with purified human or rat MAO A. The 1.8 脜 structure of the MAO B complex demonstrates that it binds within the substrate cavity.