Antimalarial Linear Lipopeptides from a Panamanian Strain of the Marine Cyanobacterium Lyngbya majuscula
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- 作者：Kerry L. McPhail ; Jhonny Correa ; Roger G. Linington ; José ; Gonzá ; lez ; Eduardo Ortega-Barrí ; a ; Todd L. Capson ; William H. Gerwick
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：June 2007
- 年：2007
- 卷：70
- 期：6
- 页码：984 - 988
- 全文大小：63K
- 年卷期：v.70,no.6(June 2007)
- ISSN：1520-6025
文摘
As part of the Panama International Cooperative Biodiversity Groups (ICBG) project, two new (2, 4) and two known(1, 3) linear alkynoic lipopeptides have been isolated from a Panamanian strain of the marine cyanobacterium Lyngbyamajuscula. Carmabin A (1), dragomabin (2), and dragonamide A (3) showed good antimalarial activity (IC50 4.3, 6.0,and 7.7 
M, respectively), whereas the nonaromatic analogue, dragonamide B (4), was inactive. The planar structuresof all four compounds were determined by NMR spectroscopy in combination with mass spectrometry, and theirstereoconfigurations were established by chiral HPLC and by comparison of their optical rotations and NMR data withliterature values.
M, respectively), whereas the nonaromatic analogue, dragonamide B (4), was inactive. The planar structuresof all four compounds were determined by NMR spectroscopy in combination with mass spectrometry, and theirstereoconfigurations were established by chiral HPLC and by comparison of their optical rotations and NMR data withliterature values.