文摘
Bioassay-guided fractionation of the MeOH extract from the octocoral Muricea austera collected in the Pacific coastof Panama led to the isolation of eight compounds, including three tyramine derivatives (1-3), two steroidal pregnaneglycosides (4, 5), and three sesquiterpenoids (6-8). Compounds 2-5 are new natural products, and their structureswere determined on the basis of their spectroscopic data (HRMS, 1D and 2D NMR, and CD studies). The antiprotozoalactivities of the natural compounds 1-8 as well as those of a series of synthetic glycosides (11-22) and tyraminederivatives (23-35) were evaluated in vitro against a drug-resistant Plasmodium falciparum and intracellular form ofTrypanosoma cruzi.