The micro
bial a
bility to resist stressful environmental conditions and chemical inhi
bitors is of great industrial and medical interest. Much of the data related to mutation-
based stress resistance, however, is scattered through the academic literature, making it difficult to apply systematic analyses to this wealth of information. To address this issue, we introduce the Resistome data
base: a literature-curated collection of
Escherichia coli genotypes–phenotypes containing over 5,000 mutants that resist hundreds of compounds and environmental conditions. We use the Resistome to understand our current state of knowledge regarding resistance and to detect potential synergy or antagonism
between resistance phenotypes. Our data set represents one of the most comprehensive collections of genomic data related to resistance currently availa
ble. Future development will focus on the construction of a com
bined genomic–transcriptomic–proteomic framework for understanding
E. coli’s resistance
biology. The Resistome can
be downloaded at
bitbucket.org/jdwinkler/resistome_release/overview" class="extLink">https://bitbucket.org/jdwinkler/resistome_release/overview.