Monoalkylglycerol Ether Lipids Promote Adipogenesis

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• 作者：Edwin A. Homan ; Yun-Gon Kim ; James P. Cardia ; Alan Saghatelian
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：April 13, 2011
• 年：2011
• 卷：133
• 期：14
• 页码：5178-5181
• 全文大小：816K
• 年卷期：v.133,no.14(April 13, 2011)
• ISSN：1520-5126

文摘

The molecular mechanisms that lead to the generation of adipose tissue (adipogenesis) are of basic and biomedical interest. Cellular models of adipogenesis have proven extremely valuable in defining biomolecules鈥攑rimarily genes and proteins鈥攖hat regulate adipogenesis. Here, the analysis of differentiating adipocytes using an untargeted metabolomics approach led to the discovery of the monoalkylglycerol ethers as a natural class of adipocyte differentiation factors.