Ligerin, an Antiproliferative Chlorinated Sesquiterpenoid from a Marine-Derived Penicillium Strain

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• 作者：Marieke Vansteelandt ; Elodie Blanchet ; Maxim Egorov ; Fabien Petit ; Lo茂c Toupet ; Arnaud Bondon ; Fabrice Monteau ; Bruno Le Bizec ; Olivier P. Thomas ; Yves Fran莽ois Pouchus ; Ronan Le Bot ; Olivier Grovel
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：February 22, 2013
• 年：2013
• 卷：76
• 期：2
• 页码：297-301
• 全文大小：254K
• 年卷期：v.76,no.2(February 22, 2013)
• ISSN：1520-6025

文摘

A new chlorinated sesquiterpenoid analogue of fumagillin, ligerin (<b>1b>), was isolated from a marine-derived strain of Penicillium, belonging to the subgenus Penicillium, along with the known compounds penicillic acid (<b>2b>), orcinol, and orsellinic acid. Chemical structures were established by an interpretation of spectroscopic data including IR, UV, and HRESIMS, together with analyses of 1D and 2D NMR spectra and X-ray analysis for the determination of the absolute configuration. Ligerin (<b>1b>) displayed strong inhibitory activity against an osteosarcoma cell line. This is the first report of the isolation of a fumagillin analogue from a marine-derived Penicillium strain.