Versatile Synthesis of Rare Nucleotide Furanoses

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• 作者：Pauline Peltier ; Richard Daniellou ; Caroline Nugier-Chauvin ; Vincent Ferri&egrave ; res
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：December 6, 2007
• 年：2007
• 卷：9
• 期：25
• 页码：5227 - 5230
• 全文大小：83K
• 年卷期：v.9,no.25(December 6, 2007)
• ISSN：1523-7052

文摘

Direct activation of unprotected thioimidoyl furanosides yielded in only one step and few minutes a panel of rare uridine 5'-diphospho-furanoses. Diastereoselectivity of the reaction was tightly connected with reaction time, temperature, and nature of the furanosyl donor. Thisapproach was totally selective since no ring expansion from the initial five-membered ring to the more stable pyranose form was observed.