Copper-Catalyzed Electrophilic Carbofunctionalization of Alkynes to Highly Functionalized Tetrasubstituted Alkenes

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• 作者：Marcos G. Suero ; Elliott D. Bayle ; Beatrice S. L. Collins ; Matthew J. Gaunt
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：April 10, 2013
• 年：2013
• 卷：135
• 期：14
• 页码：5332-5335
• 全文大小：341K
• 年卷期：v.135,no.14(April 10, 2013)
• ISSN：1520-5126

文摘

Copper catalysts enable the electrophilic carbofunctionalization of alkynes with vinyl- and diaryliodonium triflates. The new process forms highly substituted alkenyl triflates from a range of alkynes via a pathway that is opposite to classical carbometalation. The alkenyl triflate products can be elaborated through cross-coupling reactions to generate synthetically useful tetrasubstituted alkenes