Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum
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- 作者：Karlee A. Rees ; Cindy Bermudez ; David J. Edwards ; Alysha G. Elliott ; Jovita E. Ripen ; Cynthia Seta ; Johnny X. Huang ; Matthew A. Cooper ; James A. Fraser ; Tiong Chia Yeo ; Mark S. Butler
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：August 28, 2015
- 年：2015
- 卷：78
- 期：8
- 页码：2141-2144
- 全文大小：235K
- ISSN：1520-6025
文摘
In an ongoing program to identify new anti-infective leads, an extract derived from whole plant material of Desmodium congestum collected in the Sarawak rainforest was found to have anti-MRSA activity. Bioassay-guided isolation led to the isolation of two new prenylated chalcones, 5鈥?O-methyl-3-hydroxyflemingin A (1) and 5鈥?O-methylflemingin C (2), which were closely related to the flemingins previously isolated from various Flemingia species. Chalcones 1 and 2, which were determined to be 4:6 enantiomeric mixtures by chiral HPLC, exhibited moderate activity against a panel of Gram-positive bacteria and were also cytotoxic to the HEK293 human embryonic kidney cell line.