Intramolecular Diels-Alder and Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles
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- 作者：Gordon D. Wilkie ; Gregory I. Elliott ; Brian S. J. Blagg ; Scott E. Wolkenberg ; Danielle R. Soenen ; Michael M. Miller ; Scott Pollack ; and Dale L. Boger
- 刊名：Journal of the American Chemical Society
- 出版年：2002
- 出版时间：September 25, 2002
- 年：2002
- 卷：124
- 期：38
- 页码：11292 - 11294
- 全文大小：147K
- 年卷期：v.124,no.38(September 25, 2002)
- ISSN：1520-5126
文摘
The scope of intramolecular Diels-Alder and a novel tandem Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles is disclosed. In the cases examined, the tandem cycloadditions construct three new rings with formation of four new C-C bonds and set all six stereocenters about a central six-membered ring in a single step including three contiguous and four total quaternary centers without a trace of a second diastereomer.