Antiplasmodial Metabolites Isolated from the Marine Octocoral Muricea austera

详细信息    查看全文

• 作者：Marcelino Gutié ; rrez ; Todd L. Capson ; Hé ; ctor M. Guzm&aacute ; n ; José ; Gonz&aacute ; lez ; Eduardo Ortega-Barrí ; a ; Emilio Quiñ ; o&aacute ; Ricardo Riguera
• 刊名：Journal of Natural Products
• 出版年：2006
• 出版时间：October 2006
• 年：2006
• 卷：69
• 期：10
• 页码：1379 - 1383
• 全文大小：92K
• 年卷期：v.69,no.10(October 2006)
• ISSN：1520-6025

文摘

Bioassay-guided fractionation of the MeOH extract from the octocoral Muricea austera collected in the Pacific coastof Panama led to the isolation of eight compounds, including three tyramine derivatives (1-3), two steroidal pregnaneglycosides (4, 5), and three sesquiterpenoids (6-8). Compounds 2-5 are new natural products, and their structureswere determined on the basis of their spectroscopic data (HRMS, 1D and 2D NMR, and CD studies). The antiprotozoalactivities of the natural compounds 1-8 as well as those of a series of synthetic glycosides (11-22) and tyraminederivatives (23-35) were evaluated in vitro against a drug-resistant Plasmodium falciparum and intracellular form ofTrypanosoma cruzi.