Iron Oxide Monocrystalline Nanoflowers for Highly Efficient Magnetic Hyperthermia
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- 作者：Pierre Hugounenq ; Michael Levy ; Damien Alloyeau ; Lena茂c Lartigue ; Emmanuelle Dubois ; Val茅rie Cabuil ; Christian Ricolleau ; St茅phane Roux ; Claire Wilhelm ; Florence Gazeau ; Rana Bazzi
- 刊名：The Journal of Physical Chemistry C
- 出版年：2012
- 出版时间：July 26, 2012
- 年：2012
- 卷：116
- 期：29
- 页码：15702-15712
- 全文大小：640K
- 年卷期：v.116,no.29(July 26, 2012)
- ISSN：1932-7455
文摘
Magnetic nanoparticles exhibit a high potential to selectively treat cancer by hyperthermia provided that high heating capacity can be reached. In this work, we report an efficient synthesis of novel structures of magnetic iron oxide. The particles, obtained by applying a modified 鈥減olyol鈥?protocol, present a particular shape: they look constituted of smaller grains of approximately 11 nm, assembled in a flower-shaped structure. These nanoflowers, dispersed in water at physiological pH, present particularly interesting magnetic properties and a great capacity of heating. The value of the specific loss power (SLP) of these nanoflowers is 1 order of magnitude higher than the SLP reported for conventional 11 nm single-domain maghemite nanoparticles in the same condition of field exposure.