Tandem Ruthenium-Catalyzed Transfer-Hydrogenative Cyclization/Intramolecular Diels鈥揂lder Reaction of Enediynes Affording Dihydrocoumarin-Fused Polycycles

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• 作者：Yoshihiko Yamamoto ; Kazuma Matsui ; Masatoshi Shibuya
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 21, 2014
• 年：2014
• 卷：16
• 期：6
• 页码：1806-1809
• 全文大小：325K
• 年卷期：v.16,no.6(March 21, 2014)
• ISSN：1523-7052

文摘

A tandem transfer-hydrogenative cyclization/intramolecular Diels鈥揂lder reaction of enediyne substrates, containing 1,6-diyne, acrylate dienophile, and phenol tether moieties, was successfully accomplished using the combination of a cationic ruthenium complex, [CpRu(AN)₃]PF₆ (1b, Cp = 畏⁵-C₅H₅, AN = MeCN), as the catalyst and a Hantzsch ester as the H₂ surrogate to afford interesting dihydrocoumarin-fused polycyclic products as single diastereomers.