Aromatic π-Conjugated Curcumin on Surface Modified Polyaniline/Polyhydroxyalkanoate Based 3D Porous Scaffolds for Tissue Engineering Applications

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• 作者：Nilkamal Pramanik ; Kingshuk Dutta ; Ranjan K. Basu ; Patit P. Kundu
• 刊名：ACS Biomaterials Science & Engineering
• 出版年：2016
• 出版时间：December 12, 2016
• 年：2016
• 卷：2
• 期：12
• 页码：2365-2377
• 全文大小：868K
• ISSN：2373-9878

文摘

Curcumin-entrapped polyaniline (PAni)-conjugated poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) electroconductive porous scaffolds were fabricated for application in tissue engineering. The physical and chemical characterizations of the as-prepared biomaterials were performed by UV–vis and ATR/FT-IR spectrophotometric, thermogravimetric, fluorescence microscopic, and X-ray diffractometric analyses. It was observed that compared to the pure PHBV copolymer, which is an insulator, the electroconductivity of the PAni-modified PHBV copolymer increased up to the value of 5.78 × 10^–5 S cm^–1. An antimicrobial study revealed that the curcumin-loaded biomaterials exhibited better bactericidal effect against Gram-positive bacterial strains compared to Gram-negative strains. The composite also demonstrated significant compatibility toward blood and fibroblast cells and exhibited the maximum cell viability (90% to 80%). Cell migration and proliferation on the injured tissues were found to occur at a faster rate, resulting in faster repair, in the presence of anti-inflammatory and anticancer curcumin drug loaded composites compared to that of the pure PHBV copolymer.