Polyfunctional Binding of Thymidine 5'-Triphosphate with a Synthetic Polyammonium Receptor Containing Aromatic Groups. Crystal Structure of the Nucleotide-Receptor Adduct

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• 作者：Carla Bazzicalupi ; Andrea Bencini ; Antonio Bianchi ; Enrico Faggi ; Claudia Giorgi ; Samuele Santarelli ; Barbara Valtancoli
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：February 27, 2008
• 年：2008
• 卷：130
• 期：8
• 页码：2440 - 2441
• 全文大小：87K
• 年卷期：v.130,no.8(February 27, 2008)
• ISSN：1520-5126

文摘

The protonated forms of the new polyfunctional polyamine receptors L, containing two terpyridine units linked together by two diamine spacers, interact with the nucleotide thymidine 5'-triphosphate (TTP) to form stable adducts in aqueous solution. Both solution studies and the crystal structure of the [(H₄L)HTTP]·12H₂O adduct show that tight association of the two partners is achieved by the formation of hydrogen bonds and salt bridges involving the ammonium groups of L and TTP phosphate oxygen atoms and multiple interactions of the nucleobase with aliphatic and aromatic groups of the ligand, mimicking the modes of interaction of TTP binding proteins.