Layer-by-Layer Assembly of Nacre-like Nanostructured Composites with Antimicrobial Properties
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- 作者：Paul Podsiadlo ; Stephen Paternel ; Jean-Marie Rouillard ; Zhengfei Zhang ; Jaebeom Lee ; Jung-Woo Lee ; Erdogan Gulari ; and Nicholas A. Kotov
- 刊名：Langmuir
- 出版年：2005
- 出版时间：December 6, 2005
- 年：2005
- 卷：21
- 期：25
- 页码：11915 - 11921
- 全文大小：482K
- 年卷期：v.21,no.25(December 6, 2005)
- ISSN：1520-5827
文摘
In a recent report, we have presented the layer-by-layer (LBL) assembly of a biomimetic nanostructuredcomposite from Na+-montmorillonite clay nanosheets and poly(diallylmethylammonium chloride) (Tang,Z.; Kotov, N.; Magonov, S.; Ozturk, B. Nat. Mater. 2003, 2, 413). The structure, deformation mechanism,and mechanical properties of the material are very similar to those of natural nacre and lamellar bones.This fact prompts further investigation of these composites as potential bone implants. LBL assemblyaffords preparation of multifunctional composites, and here we demonstrate that not only mechanicalstrength, but also antibacterial activity, can be introduced in these implantable materials by alternatingclay layers with starch-stabilized silver nanoparticles. The resulting composite showed excellent structuralstability with no detectable levels of silver lost over a 1 month period. Evaluation of the antibacterialproperties showed almost complete growth inhibition of E. coli over an 18 h period. The amount of silvereluted from the LBL composite over a 1 month period was determined to be only 0.5-3.0 
g/L. Thisconcentration of silver did not prevent the growth of the mammalian tissue cultures. The LBL compositehas shown biocompatibility with the human osteoblast cell line.
g/L. Thisconcentration of silver did not prevent the growth of the mammalian tissue cultures. The LBL compositehas shown biocompatibility with the human osteoblast cell line.