Solid-Phase Synthesis of Novel Trimers Containing a Phenylstatine Core and Analysis by High-Resolution Magic Angle Spinning

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• 作者：Lorena Taboada ; Lourdes Prieto ; Paloma Vidal ; Juan F. Espinosa ; Jon A. Erickson
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：9
• 期：5
• 页码：748 - 755
• 全文大小：244K
• 年卷期：v.9,no.5(September 2007)
• ISSN：1520-4774

文摘

Here we describe a multistep solid-phase synthetic approach for the addition of amino acid residues to boththe C- and N-termini of a phenylstatine core, yielding a library aimed at the development of structure-activity relationships in the S2 and S2' regions of the aspartyl proteases. Optimization of the syntheticstrategy was performed on the basis of the in situ analysis of the compounds bound to the solid supportthrough high-resolution magic angle spinning NMR Spectroscopy (HR-MAS NMR).