Peptide Ligation Catalyzed by Functionalized Gold Nanoparticles
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- 作者：Yannick Fillon ; Ayush Verma ; Partha Ghosh ; Dawn Ernenwein ; Vincent M. Rotello ; Jean Chmielewski
- 刊名：Journal of the American Chemical Society
- 出版年：2007
- 出版时间：May 30, 2007
- 年：2007
- 卷：129
- 期：21
- 页码：6676 - 6677
- 全文大小：72K
- 年卷期：v.129,no.21(May 30, 2007)
- ISSN：1520-5126
文摘
Trimethylammonium functionalized gold nanoparticles are demonstrated as templates for the assembly of peptide fragments and their subsequently promoted ligation. This system displays the use of organically tailored nanoparticles as effective supramolecular reagents for catalyzing bond-forming reactions and may also serve as a model for prebiotic conditions where charged surfaces may have promoted the polymerization of the early biopolymers.