Effect of Tannins from Quercus suber and Quercus coccifera Leaves on Ethanol-Induced Gastric Lesions in Mice
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- 作者：Seddik Khennouf ; Hassiba Benabdallah ; Kamel Gharzouli ; Smain Amira ; Hideyuki Ito ; Tae-Hoon Kim ; Takashi Yoshida ; and Akila Gharzouli
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2003
- 出版时间：February 26, 2003
- 年：2003
- 卷：51
- 期：5
- 页码：1469 - 1473
- 全文大小：86K
- 年卷期：v.51,no.5(February 26, 2003)
- ISSN：1520-5118
文摘
The gastroprotective effects of 70% acetone extracts of Quercus suber and Quercus coccifera leavesand of tannins (pedunculagin, castalagin, phillyraeoidin A, and acutissimin B) purified from theseextracts were examined in the mouse using the ethanol-induced gastric ulcer model. Both extracts(25, 50, and 100 mg/kg), given orally, prevented the formation of ethanol-induced lesions in thestomach. The percent protection varied between 68 and 91%. Purified tannins (50 mg/kg) were alsoeffective in protecting the stomach against ethanol, and the percent protection varied from 66 to83%. Castalagin was the most potent. Both extracts and all of the tannins tested (10, 25, and 50
g/mL) strongly inhibited (55-65%) the lipid peroxidation of rabbit brain homogenate. These resultssuggest that the gastroprotective effects of extracts of Q. suber and Q. coccifera leaves and thepurified tannins in this experimental model are related to their anti-lipoperoxidant properties.Keywords: Experimental gastric ulcer; lipid peroxidation; medicinal plants; Quercus sp.; tannins;castalagin
g/mL) strongly inhibited (55-65%) the lipid peroxidation of rabbit brain homogenate. These resultssuggest that the gastroprotective effects of extracts of Q. suber and Q. coccifera leaves and thepurified tannins in this experimental model are related to their anti-lipoperoxidant properties.Keywords: Experimental gastric ulcer; lipid peroxidation; medicinal plants; Quercus sp.; tannins;castalagin