Differential Self-Assembly Behaviors of Cyclic and Linear Peptides

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• 作者：Sung-ju Choi ; Woo-jin Jeong ; Seong-Kyun Kang ; Myongsoo Lee ; Eunhye Kim ; Du Yeol Ryu ; Yong-beom Lim
• 刊名：Biomacromolecules
• 出版年：2012
• 出版时间：July 9, 2012
• 年：2012
• 卷：13
• 期：7
• 页码：1991-1995
• 全文大小：372K
• 年卷期：v.13,no.7(July 9, 2012)
• ISSN：1526-4602

文摘

Here we ask the fundamental questions about the effect of peptide topology on self-assembly. The study revealed that the self-assembling behaviors of cyclic and linear peptides are significantly different in several respects, in addition to sharing several similarities. Their clear differences included the morphological dissimilarities of the self-assembled nanostructures and their thermal stability. The similarities include their analogous critical aggregation concentration values and cytotoxicity profiles, which are in fact closely related. We believe that understanding topology-dependent self-assembly behavior of peptides is important for developing tailor-made self-assembled peptide nanostructures.