Heterologous Production of 4-O-Demethylbarbamide, a Marine Cyanobacterial Natural Product
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- 作者：Eun Ji Kim ; Jong Hyun Lee ; Hyukjae Choi ; Alban R. Pereira ; Yeon Hee Ban ; Young Ji Yoo ; Eunji Kim ; Je Won Park ; David H. Sherman ; William H. Gerwick ; Yeo Joon Yoon
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：December 7, 2012
- 年：2012
- 卷：14
- 期：23
- 页码：5824-5827
- 全文大小：217K
- 年卷期：v.14,no.23(December 7, 2012)
- ISSN：1523-7052
文摘
Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.