Enzymatic AND Logic Gate with Sigmoid Response Induced by Photochemically Controlled Oxidation of the Output

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• 作者：Vladimir Privman ; Brian E. Fratto ; Oleksandr Zavalov ; Jan Hal谩mek ; Evgeny Katz
• 刊名：The Journal of Physical Chemistry B
• 出版年：2013
• 出版时间：June 27, 2013
• 年：2013
• 卷：117
• 期：25
• 页码：7559-7568
• 全文大小：528K
• 年卷期：v.117,no.25(June 27, 2013)
• ISSN：1520-5207

文摘

We report a study of a system which involves an enzymatic cascade realizing an AND logic gate, with an added photochemical processing of the output, allowing the gate鈥檚 response to be made sigmoid in both inputs. New functional forms are developed for quantifying the kinetics of such systems, specifically designed to model their response in terms of signal and information processing. These theoretical expressions are tested for the studied system, which also allows us to consider aspects of biochemical information processing such as noise transmission properties and control of timing of the chemical and physical steps.