The Dynamic Character of the G-Quadruplex Element in the c-MYC Promoter and Modification by TMPyP4
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- 作者：Jeyaprakashnarayanan Seenisamy ; Evonne M. Rezler ; Tiffanie J. Powell ; Denise Tye ; Vijay Gokhale ; Chandana Sharma Joshi ; Adam Siddiqui-Jain ; and Laurence H. Hurley
- 刊名：Journal of the American Chemical Society
- 出版年：2004
- 出版时间：July 21, 2004
- 年：2004
- 卷：126
- 期：28
- 页码：8702 - 8709
- 全文大小：328K
- 年卷期：v.126,no.28(July 21, 2004)
- ISSN：1520-5126
文摘
The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters ofc-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this regioncan form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We havedemonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loopisomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.