Microfabricated Gas Chromatograph for Rapid, Trace-Level Determinations of Gas-Phase Explosive Marker Compounds

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• 作者：William R. Collin ; Gustavo Serrano ; Lindsay K. Wright ; Hungwei Chang ; Nicol谩s Nu帽overo ; Edward T. Zellers
• 刊名：Analytical Chemistry
• 出版年：2014
• 出版时间：January 7, 2014
• 年：2014
• 卷：86
• 期：1
• 页码：655-663
• 全文大小：410K
• ISSN：1520-6882

文摘

A prototype microfabricated gas chromatograph (渭GC) adapted specifically for the rapid determination of selected gas-phase marker compounds of the explosive 2,4,6-trinitrotoluene (TNT) at sub-parts-per-billion (<ppb) concentrations in complex mixtures is described. Si-microfabricated focuser, separation column, and sensor array components are integrated with a high-volume sampler of conventional construction to reduce analysis time and the limit of detection (LOD). The primary markers selected as target analytes were 2,4-dinitrotoluene (2,4-DNT, a persistent impurity of TNT) and 2,3-dimethyl-2,3-dinitrobutane (DMNB, a taggant), along with 2,6-dinitrotoluene (2,6-DNT, a less-prominent TNT impurity), which was also included in numerous tests. Selective preconcentration, on-column focusing, temperature-programmed chromatographic separation, and sensor array detection/recognition facilitated determinations of the primary markers in the presence of 20 (or more) interferences within 2 min under laptop control. Estimated LODs of 2.2, 0.48, and 0.86 ng were achieved for DMNB, 2,6-DNT, and 2,4-DNT, respectively, which correspond to 0.30, 0.067, and 0.12 ppb in each 1-L air sample collected.