Three-Component Reaction of a 2-Aminoazine, a 2-Oxoaldehyde, and a Cyclic 1,3-Dicarbonyl Compound for the Synthesis of Imidazo[1,2-a]azine Derivatives
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- 作者：Vsevolod A. Peshkov ; Anatoly A. Peshkov ; Olga P. Pereshivko ; Kristof Van Hecke ; Lali L. Zamigaylo ; Erik V. Van der Eycken ; Nikolay Yu. Gorobets
- 刊名：ACS Combinatorial Science
- 出版年：2014
- 出版时间：October 13, 2014
- 年：2014
- 卷：16
- 期：10
- 页码：535-542
- 全文大小：479K
- ISSN：2156-8944
文摘
A three-component reaction of a 2-aminoazine, a 2-oxoaldehyde, and a cyclic 1,3-dicarbonyl compound providing access toward a novel class of imidazo[1,2-a]azine derivatives was developed and studied. The scope of the process was thoroughly explored under three different reaction conditions resulting in the generation of a small library of title compounds and highlighting the possibility of case-specific approach.