Novel Substituted Aminoalkylguanidines as Potential Antihyperglycemic and Food Intake-Reducing Agents
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- 作者：Emanuela Tassoni ; Fabio Giannessi ; Tiziana Brunetti ; Pompeo Pessotto ; Michela Renzulli ; Massimiliano Travagli ; Suvi Rajamä ; ki ; Samanta Prati ; Secondo Dottori ; Federico Corelli ; Walter Cabri ; Paolo
- 刊名：Journal of Medicinal Chemistry
- 出版年：2008
- 出版时间：June 12, 2008
- 年：2008
- 卷：51
- 期：11
- 页码：3073 - 3076
- 全文大小：136K
- 年卷期：v.51,no.11(June 12, 2008)
- ISSN：1520-4804
文摘
We report the synthesis and evaluation of aminoalkylguanidine analogues and derivatives in C57BL/KsJ db/db diabetic mice, following identification by random screening of 1a and 1b as potential antihyperglycemics and/or modulators of food intake. These compounds are related to galegine, a γ,γ-dimethylallylguanidine. Between the newly identified compounds, 1h N-(cyclopropylmethyl)-N′-(4-(aminomethyl)cyclohexylmethyl)guanidine showed the most balanced activity as antihyperglycemic and food intake-reducing agent.