Metal鈥揙rganic-Framework-Based Tandem Molecular Sieves as a Dual Platform for Selective Microextraction and High-Resolution Gas Chromatographic Separation of n-Alkanes in Complex Matrixes

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• 作者：Na Chang ; Zhi-Yuan Gu ; He-Fang Wang ; Xiu-Ping Yan
• 刊名：Analytical Chemistry
• 出版年：2011
• 出版时间：September 15, 2011
• 年：2011
• 卷：83
• 期：18
• 页码：7094-7101
• 全文大小：864K
• 年卷期：v.83,no.18(September 15, 2011)
• ISSN：1520-6882

文摘

Metal鈥搊rganic frameworks (MOFs) were employed to design tandem molecular sieves as a dual platform for selective solid-phase microextraction (SPME) and high-resolution gas chromatographic (GC) separation of target analytes in complex matrixes. An elegant combination of a ZIF-8-coated fiber for SPME with a ZIF-8-coated capillary for GC allows selective extraction and separation of n-alkanes from complex matrixes such as petroleum-based fuel and biological fluids. The proposed tandem ZIF-8 molecular sieves not only offered good enhancement factors from 235 (hexane) to 1212 (nonane), but also exhibited wide linearity with 3 orders of magnitude for the tested linear alkanes. The limits of detection for the linear alkanes ranged from 0.46 ng L^鈥? (nonane) to 1.06 ng L^鈥?(hexane). The relative standard deviations of retention time, peak area, peak height, and half peak width for five replicate determinations of the tested n-alkanes at 30 ng L^鈥? were 0.02鈥?.26%, 1.9鈥?.6%, 1.4鈥?.0%, and 1.3鈥?.2%, respectively. The developed tandem ZIF-8 molecular sieves were further used for the determination of linear alkanes in petroleum-based fuel and human serum. The large diversity in structure and pore size allows various combinations of MOFs for designing an MOF-based tandem molecular sieve platform to achieve different selectivities in extraction and chromatographic separation and to solve headache problems in complex real sample analysis.