Copper-Catalyzed Intramolecular C鈭扤 Bond Formation: A Straightforward Synthesis of Benzimidazole Derivatives in Water

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• 作者：Jinsong Peng ; Min Ye ; Cuijuan Zong ; Fangyun Hu ; Lingtong Feng ; Xiaoyan Wang ; Yufeng Wang ; Chunxia Chen
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：January 21, 2011
• 年：2011
• 卷：76
• 期：2
• 页码：716-719
• 全文大小：776K
• 年卷期：v.76,no.2(January 21, 2011)
• ISSN：1520-6904

文摘

A straightforward, efficient, and more sustainable copper-catalyzed method has been developed for intramolecular N-arylation providing the benzimidazole ring system. With Cu₂O (5 mol %) as the catalyst, DMEDA (10 mol %) as the ligand, and K₂CO₃ as the base, this protocol was applied to synthesize a small library of benzimidazoles in high yields. Remarkably, the reaction was exclusively carried out in water, rendering the methodology highly valuable from both environmental and economical points of view.