Bioactive Dammarane-Type Saponins from Operculina turpethum

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• 作者：Wenbing Ding ; Fanli Zeng ; Liangxiong Xu ; Yunyun Chen ; Yifei Wang ; Xiaoyi Wei
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：September 23, 2011
• 年：2011
• 卷：74
• 期：9
• 页码：1868-1874
• 全文大小：774K
• 年卷期：v.74,no.9(September 23, 2011)
• ISSN：1520-6025

文摘

Four new dammarane-type saponins, operculinosides A鈥揇 (1鈥?b>4), were isolated from the aerial parts of Operculina turpethum, of which 1 and 2 are the first two dammarane-type triterpenoids having an oxymethyl group at C-24. Their structures were determined by spectroscopic analysis and acid hydrolysis. The absolute configuration of operculinoside A (1) was confirmed by X-ray crystallography. Compounds 1 and 3 showed significant protective activities against d-galactosamine-induced toxicity in L-02 human hepatic cells.