Copper-Catalyzed Debenzoylative Monofluoromethylation of Aryl Iodides Assisted by the Removable (2-Pyridyl)sulfonyl Group

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• 作者：Yanchuan Zhao ; Chuanfa Ni ; Fanzhou Jiang ; Bing Gao ; Xiao Shen ; Jinbo Hu
• 刊名：ACS Catalysis
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：3
• 期：4
• 页码：631-634
• 全文大小：299K
• 年卷期：v.3,no.4(April 5, 2013)
• ISSN：2155-5435

文摘

A new method for aromatic monofluoromethylation was developed. Aryl iodides can be efficiently transformed into the corresponding monofluoromethylated products by a copper-catalyzed debenzoylative fluoroalkylation with 2-PySO₂CHFCOR and subsequent reductive desulfonylation. The (2-pyridyl)sulfonyl moiety plays an important role in the copper-catalyzed cross-coupling, and it can be removed easily through Bu₃SnH-mediated desulfonylation.

Keywords:

monofluoromethylation; copper catalysis; (2-pyridy)sulfonyl group; cross-coupling; fluorine