Hydrangenone, a New Isoprenoid with an Unprecedented Skeleton from Salvia hydrangea

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• 作者：M. Moridi Farimani ; Salman Taheri ; Samad N. Ebrahimi ; M. Babak Bahadori ; Hamid R. Khavasi ; Stefanie Zimmermann ; Reto Brun ; Matthias Hamburger
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 6, 2012
• 年：2012
• 卷：14
• 期：1
• 页码：166-169
• 全文大小：745K
• 年卷期：v.14,no.1(January 6, 2012)
• ISSN：1523-7052

文摘

Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic methods. The relative and absolute configuration of 1 was assigned by NOESY and X-ray crystallographic analysis and by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed in vitro antiplasmodial activity, with an IC₅₀ value of 1.4 渭M against P. falciparum. A plausible biosynthetic pathway of 1 was also proposed.