Antitrypanosomal Triterpenoid with an 蔚-Lactone E-Ring from Salvia urmiensis

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• 作者：Mahdi Moridi Farimani ; Samad Nejad Ebrahimi ; Peyman Salehi ; Mir Babak Bahadori ; Ali Sonboli ; Hamid Reza Khavasi ; Stefanie Zimmermann ; Marcel Kaiser ; Matthias Hamburger
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：September 27, 2013
• 年：2013
• 卷：76
• 期：9
• 页码：1806-1809
• 全文大小：289K
• 年卷期：v.76,no.9(September 27, 2013)
• ISSN：1520-6025

文摘

A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute configuration was established by comparison of experimental and simulated ECD spectra. Urmiensolide is the first pentacyclic triterpenoid bearing a 蔚-lactone E-ring. The compound showed in vitro antitrypanosoal activity with an IC₅₀ value of 5.6 渭M against the Trypanosoma brucei rhodesiense STIB 900 strain and a selectivity index of 33. A possible biosynthetic pathway of 1 from 伪-amyrin is proposed.