Organophosphonate Functionalized Gd@C82 as a Magnetic Resonance Imaging Contrast Agent

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• 作者：Chun-Ying Shu ; Chun-Ru Wang ; Jian-Fei Zhang ; Harry W. Gibson ; Harry C. Dorn ; Frank D. Corwin ; Panos P. Fatouros ; T. John S. Dennis
• 刊名：Chemistry of Materials
• 出版年：2008
• 出版时间：March 25, 2008
• 年：2008
• 卷：20
• 期：6
• 页码：2106 - 2109
• 全文大小：229K
• 年卷期：v.20,no.6(March 25, 2008)
• ISSN：1520-5002

文摘

A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM⁻¹ s⁻¹) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM⁻¹ s⁻¹) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C₈₂ (16.0 mM⁻¹ s⁻¹) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.