Spirocurcasone, a Diterpenoid with a Novel Carbon Skeleton from Jatropha curcas

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• 作者：Giuseppina Chianese ; Ernesto Fattorusso ; Olapeju O. Aiyelaagbe ; Paolo Luciano ; Heinz C. Schro虉der ; Werner E. G. Mu虉ller ; Orazio Taglialatela-Scafati
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：January 21, 2011
• 年：2011
• 卷：13
• 期：2
• 页码：316-319
• 全文大小：199K
• 年卷期：v.13,no.2(January 21, 2011)
• ISSN：1523-7052

文摘

Spirocurcasone (14), a diterpenoid possessing the unprecedented 鈥渟pirorhamnofolane鈥?skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line.