Chiral γ-Aryl-1H-1,2,4-triazole Derivatives as Highly Potential Antifungal Agents: Design, Synthesis, Structure, and in Vitro Fungicidal Activities

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• 作者：Xiufang Cao ; Fei Li ; Ming Hu ; Wenchang Lu ; Guang-Ao Yu ; Sheng Hua Liu
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2008
• 出版时间：December 10, 2008
• 年：2008
• 卷：56
• 期：23
• 页码：11367-11375
• 全文大小：234K
• 年卷期：v.56,no.23(December 10, 2008)
• ISSN：1520-5118

文摘

A novel series of chiral γ-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents have been designed and synthesized conveniently by using the chiral auxiliary as a controlling reagent. All of the compounds exhibit moderate to high ee values reaching up to 99%, and the preliminary bioassay results demonstrated that most of the target compounds take on a significantly wide spectrum activity against Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria, and Colletotrichum gossypii species.