Convergent Formal Synthesis of (卤)-Roseophilin

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• 作者：Chuanjun Song ; Hui Liu ; Meiling Hong ; Yuanyuan Liu ; Feifei Jia ; Li Sun ; Zhenliang Pan ; Junbiao Chang
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：January 6, 2012
• 年：2012
• 卷：77
• 期：1
• 页码：704-706
• 全文大小：204K
• 年卷期：v.77,no.1(January 6, 2012)
• ISSN：1520-6904

文摘

A facile convergent synthesis of the tricyclic core 2 of roseophilin is described, which represents the shortest route so far for the formal synthesis of roseophilin. The key step was a tandem pyrrole acylation-Nazarov cyclization reaction to form the cyclopenta[b]pyrrole moiety 4.